compound 3a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4356	POL1-IN-1	Compound 3A	DNA/RNA Synthesis
	POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.		DNA/RNA Synthesis
T77671	GSK3a-IN-38		GSK-3
	GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.		GSK-3
T73521	Nec-3a
	Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 μM. This compound successfully impedes the autophosphorylation activity within the RIP1 kinase domain.
T73834	NS5A-IN-2		HCV Protease
	NS5A-IN-2 (Compound 33) serves as a potent NS5A inhibitor exhibiting exceptional efficacy against HCV genotype 1b, enhanced activity against genotype 3a (GT 3a), and notable metabolic stability [1].		HCV Protease
T73223	NS5A-IN-3		HCV Protease
	NS5A-IN-3 (Compound 15) serves as a potent NS5A inhibitor, displaying exceptionally high efficacy against HCV genotype 1b, enhanced activity towards genotype 3a (GT 3a), and substantial metabolic stability. It also demon...		HCV Protease
T78911	Antitumor agent-112		Apoptosis
	Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35 μM [1].		Apoptosis
T131422	D20,23-3a,12a-diacetoxy-24,24-diphenylcholadiene
	D20,23-3a,12a-diacetoxy-24,24-diphenylcholadiene is a useful organic compound for research related to life sciences and the catalog number is T131422.
T83071	Antifungal agent 62
	Compound 3a (Antifungal agent 62) exhibits potent fungicidal properties, particularly against Fusarium oxysporum f.sp. cucumerinum, and is utilized in antiviral and fungicidal research [1].
T83081	Anticancer agent 170
	Compound 3a, an anticancer agent and ketone derivative, exhibits potent activity against the A549 cancer cell line, demonstrating an inhibitory concentration (IC50) of 6.62 μM [1].
T40893	Estrogen receptor modulator 6
	Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for...
T79415	Antiparasitic agent-18		Parasite
	Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T. brucei (EC 50 =0.4 µM), T. cruzi (EC 50 =0.21 µM), and L. donovani (EC 50 =0.26 µM) [1].		Parasite
T66653	(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol
	(2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol is a useful organic compound for research related to life sciences and the catalog number is T66653.
T61674	COX-2/5-LOX-IN-1
	COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celec...
T77876	Py-MAA-Val-Cit-PAB-MMAE	AAJ8D6-PY-Val-Cit-MMAE
	Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. By targeting TRAILR2, Zapadcine-3a is internalized into the lys...
T61417	PPARγ agonist 7
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal s...
T81689	Neohelmanthicin A
	Neohelmanthicin A (compound 3A), a phenylpropanoid with antitumor properties, exhibits IC50 values of 0.13 μM, 7 μM, and 23 μM against leukemia cell line EL4, breast cancer cell line S180, and breast cancer cell line MCF...
T78714	PptT-IN-4		Calcium Channel
	PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM. It also demonstrates antimycobacterial activity against Mtb H37Rv, with a MIC of 42 μM, and inhibits hERG, hCav1.2, and hNav1.5 channels with IC5...		Calcium Channel
T74625	HCV-IN-41
	HCV-IN-41 (compound 4), a potent inhibitor of the hepatitis C virus (HCV), demonstrates exceptional inhibitory effectiveness across different genotypes, with EC 50 values of 0.006762 nM for genotype 1b, 5.183 nM for 2a, ...
T64449	Rel-(3aR,4S,7R,7aS)-3a,4,7,7a-Tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
	rel-(3aR,4S,7R,7aS)-3a,4,7,7a-Tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione is a useful organic compound for research related to life sciences. The catalog number is T64449 and the CAS number is 6265-30-1.
T60315	Anti-infective agent 1
	Anti-infective agent 1 (compound 3a) serves as a potent, selective antiprotozoal and antimycobacterial compound. It showcases antiparasitic efficacy against P. falciparum and T. brucei rhodesiense, demonstrating IC50 val...